反应详情

A solution of 59.5 g of 3,4-dichlorophenylacetic acid in 500 ml of absolute ethanol is saturated with anhydrous hydrogen chloride and then heated at reflux for 2 hours. The mixture is concentrated under reduced pressure to 200 ml, diluted with 200 ml of water and neutralized with concentrated ammonium hydroxide. This aqueous mixture is extracted 3 times with chloroform. Concentration and decolorization of the chloroform extracts gives ethyl 3,4-dichlorophenylacetate as a yellow oil.

1. temperatureheated
2. temperatureat reflux for 2 hours
3. concentrationThe mixture is concentrated under reduced pressure to 200 ml
4. additiondiluted with 200 ml of water and neutralized with concentrated ammonium hydroxide
5. extractionThis aqueous mixture is extracted 3 times with chloroform
6. concentrationConcentration and decolorization of the chloroform