Triphenylphosphine → 3-(2'-amino-1'-methyl-5'-oxo-2-phenyl-1',5'-dihydrospiro[chroman-4,4'-imidazole]-6-yl)-N-methylbenzenesulfonamide

HRID 662856Notes

Reaction equation

HRID 662856 reaction equation
[C:45](=[O:46])([O-:47])[O-:48].[CH2:39]1[O:40][CH2:41][CH2:42][O:43][CH2:44]1.[CH3:25][NH:26][S:27](=[O:28])(=[O:29])[c:30]1[cH:31][c:32]([B:36]([OH:37])[OH:38])[cH:33][cH:34][cH:35]1.[Cs+:49].[Cs+:50].[NH2:1][C:2]1=[N:22][C:5]2([C:4](=[O:23])[N:3]1[CH3:24])[CH2:6][CH:7]([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[O:8][c:9]1[cH:10][cH:11][c:12]([Br:15])[cH:13][c:14]12.[Pd:51]([Cl:52])[Cl:53].[c:54]1([P:55]([c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[cH:68][cH:69][cH:70][cH:71][cH:72]1.[c:73]1([P:74]([c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)[c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)[cH:87][cH:88][cH:89][cH:90][cH:91]1>>[NH2:1][C:2]1=[N:22][C:5]2([C:4](=[O:23])[N:3]1[CH3:24])[CH2:6][CH:7]([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[O:8][c:9]1[cH:10][cH:11][c:12](-[c:32]3[cH:31][c:30]([S:27]([NH:26][CH3:25])(=[O:28])=[O:29])[cH:35][cH:34][cH:33]3)[cH:13][c:14]12

Participants

8

Reactant 7

HCID 11776Triphenylphosphine2×HCID 19660Carbonate IonHCID 24290Palladium ChlorideHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 44886921Methyl 3-boronobenzenesulfonamideHCID 584237682'-amino-6-bromo-1'-methyl-2-phenylspiro[chroman-4,4'-imidazol]-5'(1'H)-one

Product 1

HCID 584241853-(2'-amino-1'-methyl-5'-oxo-2-phenyl-1',5'-dihydrospiro[chroman-4,4'-imidazole]-6-yl)-N-methylbenzenesulfonamide

Sources & evidence

ORD record
ord-0385c45bb8f44f4faabe108e499b308e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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