Hydrochloric Acid → 2-Methyl-1-(p-tolyl)-3-azabicyclo[3.1.0]hexane hydrochloride

HRID 66297Notes

Reaction equation

HRID 66297 reaction equation
[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([C:7]23[CH2:12][CH:11]2[CH2:10][NH:9][C:8]3=O)=[CH:3][CH:2]=1.[CH3:15][Li].[BH4-].[Na+].[ClH:19]>CCOCC.CO>[ClH:19].[CH3:15][CH:8]1[NH:9][CH2:10][CH:11]2[C:7]1([C:4]1[CH:5]=[CH:6][C:1]([CH3:14])=[CH:2][CH:3]=1)[CH2:12]2

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 128913851-(p-Tolyl)-3-azabicyclo[3.1.0]hexan-2-oneHCID 178418348HCID 178418348, compound

Product 1

HCID 233323662-Methyl-1-(p-tolyl)-3-azabicyclo[3.1.0]hexane hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

Using the method of M. Takeda, et al., Chem. Pharm. Bull., 24, 2312 (1976), 1-(p-tolyl)-3-azabicyclo[3.1.0]hexan-2-one is reacted with methyllithium followed by sodium borohydride. Excess reagents are decomposed with methanol, followed by 1N hydrochloric acid, and then 1N sodium hydroxide and then evaporation of the solution gives a residue which is dissolved in ether. This solution is dried over sodium sulfate and filtered, and to the filtrate is added dry hydrogen chloride. Filtration of this suspension gives 2-methyl-1-(p-tolyl)-3-azabicyclo[3.1.0]hexane hydrochloride.

Workup

  1. custom1N sodium hydroxide and then evaporation of the solution
  2. customgives a residue which
  3. dry with materialThis solution is dried over sodium sulfate
  4. filtrationfiltered
  5. additionto the filtrate is added dry hydrogen chloride
  6. filtrationFiltration of this suspension

Sources & evidence

ORD record
ord-e80dc43894ef4c9388b5e16f5e5316f6
Source dataset
uspto-grants-1978_12
Patent number
US04131611

Reaction notes

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