Diethyl Ether → HCID 178479594, compound

HRID 66314Notes

Reaction equation

HRID 66314 reaction equation
[N:1]#[N:2].[CH:3]1[C:16]2[S:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[O:8][C:7]=2[CH:6]=[CH:5][C:4]=1[S:17]([NH:20][C@H:21]([C:29]([OH:31])=O)[CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:28])[NH2:27])(=[O:19])=[O:18].C(OCC)C.S(Cl)([Cl:39])=O>>[N:1]#[N:2].[ClH:39].[CH:3]1[C:16]2[S:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[O:8][C:7]=2[CH:6]=[CH:5][C:4]=1[S:17]([NH:20][C@H:21]([C:29]([Cl:39])=[O:31])[CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:28])[NH2:27])(=[O:19])=[O:18]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 24386Thionyl ChlorideHCID 178514627HCID 178514627, compound

Product 1

HCID 178479594HCID 178479594, compound

Procedure

A suspension of 3 g of N2 -(2-phenoxathiinylsulfonyl)-L-arginine in 20 ml of thionyl chloride was stirred for 2 hours at room temperature. Addition of cold dry diethyl ether resulted in a precipitate which was collected by filtration and washed several times with dry diethyl ether to give N2 -(2-phenoxathiinylsulfonyl)-L-arginyl chloride hydrochloride.

Workup

  1. customresulted in a precipitate which
  2. filtrationwas collected by filtration
  3. washwashed several times with dry diethyl ether

Sources & evidence

ORD record
ord-230cf04c0f214fd6b4278fd6736d9fdd
Source dataset
uspto-grants-1978_12
Patent number
US04131673

Reaction notes

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