Water → 2-Chloro-1-(2-methoxyphenyl)ethan-1-ol

HRID 66321Notes

Reaction equation

HRID 66321 reaction equation
CO[CH:3]([Cl:12])[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].O.[BH4-].[Na+].[O:16]1CCOC[CH2:17]1>>[Cl:12][CH2:3][CH:4]([OH:5])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=1[O:16][CH3:17]

Participants

5

Reactant 4

HCID 962WaterHCID 312751,4-DioxaneHCID 4311764Sodium borohydrideHCID 227549172-Methoxy-alpha-chloroacetophenone

Product 1

HCID 224917592-Chloro-1-(2-methoxyphenyl)ethan-1-ol

Procedure

1.7 g of 2-methoxy-α-chloroacetophenone are dissolved in 30 ml of dioxane, and 12 ml of water are added thereto. 600 mg of sodium borohydride are added gradually to the solution at 10° to 20° C. Then, the mixture is treated in the same manner as described in Example 2-(1). 1.4 g of α-chloromethyl-2-methoxybenzylalcohol are obtained as a crude oil.

Workup

  1. additionThen, the mixture is treated in the same manner

Sources & evidence

ORD record
ord-3f9bca722ccc4b99a3df1596ea863917
Source dataset
uspto-grants-1978_12
Patent number
US04131686

Reaction notes

Loading…