HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 66333Generated: October 26, 2026
Sec-Butylamine → 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one
https://huagongshe.com/reaction/66333
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sec-Butylamine | HCID 24874 | — |
| Reactant | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone | HCID 23343637 | — |
| Solvent | Diisopropyl Ether | HCID 7914 | — |
| Product | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one | HCID 22754738 | — |
Reaction Steps
A mixture of 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (8.6 g.) and sec-butylamine (40 cc.) is heated at 65° C. until dissolution. The reaction mixture is then diluted with diisopropyl ether (240 cc.). The precipitate formed is filtered off and recrystallised from acetonitrile (60 cc.). 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one (3 g.), melting at 220°-222° C., is thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04131674 |
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| Source dataset | uspto-grants-1978_12 |
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| ORD ID | ord-023d2509928949a9bbadc17115bc650a |
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| Source note | uspto-grants-1978_12 |
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