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HRID66333

反应详情

EQUATION

反应方程式

HRID 66333 的结构方程式

REACTANTS

反应物

2
结构：CCC(C)N
HCID24874

2-Butanamine

C4H11N

结构：O=C(Oc1ccccc1)OC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1
HCID23343637

未命名化合物

PRODUCTS

生成物

1
结构：CCC(C)NC(=O)OC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1
HCID22754738

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)OC(C)C
溶剂HCID7914

Isopropyl ether

C6H14O

CONDITIONS

反应条件

温度
65 °C

PROCEDURE

实验过程

A mixture of 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (8.6 g.) and sec-butylamine (40 cc.) is heated at 65° C. until dissolution. The reaction mixture is then diluted with diisopropyl ether (240 cc.). The precipitate formed is filtered off and recrystallised from acetonitrile (60 cc.). 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one (3 g.), melting at 220°-222° C., is thus obtained.

WORKUP

后处理

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. customrecrystallised from acetonitrile (60 cc.)