Hydrochloric Acid → 3,3,3-Trifluoro-1-(2-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)amino)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)propan-1-one

HRID 663475Notes

Reaction equation

HRID 663475 reaction equation
[CH3:4][O:5][c:6]1[cH:7][c:8]([NH:18][c:19]2[s:20][c:21]3[c:26]([n:27]2)[CH2:25][CH2:24][NH:23][CH2:22]3)[cH:9][cH:10][c:11]1-[n:12]1[cH:13][n:14][c:15]([CH3:17])[cH:16]1.[ClH:1].[ClH:2].[ClH:3].[F:28][C:29]([CH2:30][C:31](=[O:32])[Cl:33])([F:34])[F:35]>>[CH3:4][O:5][c:6]1[cH:7][c:8]([NH:18][c:19]2[s:20][c:21]3[c:26]([n:27]2)[CH2:25][CH2:24][N:23]([C:31]([CH2:30][C:29]([F:28])([F:34])[F:35])=[O:32])[CH2:22]3)[cH:9][cH:10][c:11]1-[n:12]1[cH:13][n:14][c:15]([CH3:17])[cH:16]1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid3×HCID 27833433,3,3-Trifluoropropionyl chlorideHCID 25106281N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4,5,6,7-tetrahydro-[1,3]thiazolo[5,4-c]pyridin-2-amine

Product 1

HCID 251062833,3,3-Trifluoro-1-(2-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)amino)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)propan-1-one

Sources & evidence

ORD record
ord-c33fce22b6834961b52d74989d566962
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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