反应详情

A mixture of 800 mg. of 2-benzyloxazolo[4,5-b]pyridine, 2.5 g. of potassium permanganate, 35 ml. of water and 6 drops of 2.5 N sodium hydroxide solution was heated at 50°-55° C. for 3 hours. After cooling, sulfuric acid was added to about pH 6 and sufficient sodium bisulfite was added to remove the manganese dioxide. The crystalline precipitate remaining was collected and recrystallized from ethylacetate to give 2-benzoyloxazolo[4,5-b]pyridine, m.p. 151°-153° C.

1. additionA mixture of 800 mg
2. temperatureAfter cooling
3. additionwas added
4. customto remove the manganese dioxide
5. customThe crystalline precipitate remaining was collected
6. customrecrystallized from ethylacetate