Benzoyl chloride → 5-Benzoylamino-2-phenyloxazolo[5,4-b]pyridine

HRID 66366Notes

Reaction equation

HRID 66366 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[O:8][C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:10][C:5]2=[CH:4][CH:3]=1.[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>N1C=CC=CC=1>[C:17]([NH:1][C:2]1[N:7]=[C:6]2[O:8][C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:10][C:5]2=[CH:4][CH:3]=1)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 227547935-Amino-2-phenyloxazolo[5,4-b]pyridine

Product 1

HCID 227547985-Benzoylamino-2-phenyloxazolo[5,4-b]pyridine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 80 mg. of 5-amino-2-phenyloxazolo[5,4-b]pyridine in 1 ml. of pyridine was treated with 0.07 ml. of benzoyl chloride. After standing 1 hour the mixture was diluted with ice-water. The precipitate was collected and recrystallized from methanol to give 5-benzoylamino-2-phenyloxazolo[5,4-b]pyridine, m.p. 191°-192° C.

Workup

  1. customThe precipitate was collected
  2. customrecrystallized from methanol

Sources & evidence

ORD record
ord-3eade76e1ede47acad219115495f1cd5
Source dataset
uspto-grants-1978_12
Patent number
US04131677

Reaction notes

Loading…