反应详情

3-(2-Fluorobenzoylamino)-2-pyridone (2 g.), 60 ml. of xylene and 15 ml. of pyridine were heated until solution was complete. To this solution was added 6.5 grams of phosphorus pentasulfide and the mixture was heated at reflux for 16 hours. The reaction mixture was decanted from a gummy residue while hot, and the solvents were concentrated to dryness. The crystalline residue was recrystallized from ethanol to give 2-(2-fluorophenyl)thiazolo[5,4-b]pyridine, m.p. 119-121° C.

1. temperaturethe mixture was heated
2. temperatureat reflux for 16 hours
3. customThe reaction mixture was decanted from a gummy residue while hot, and the solvents
4. concentrationwere concentrated to dryness
5. customThe crystalline residue was recrystallized from ethanol