反应详情

温度

175 °C

A mixture of 2.3 g. of 5-chloro-2-phenyloxazolo[5,4-b]pyridine, 1.6 g. of cuprous cyanide and 15 ml. of N-methyl pyrrolidinone is stirred under nitrogen and then heated in an oil bath of 175° C. (bath temperature). It is maintained at that temperature for 5 hours. The cooled, dark mixture is diluted with 75 ml. of 10% ammonium hydroxide and a dark precipitate removed by filtration. The solid is extracted with methylene dichloride. The methylene dichloride is evaporated and the residue crystallized from ethyl acetate.

1. additionA mixture of 2.3 g
2. temperatureIt is maintained at that temperature for 5 hours
3. additionThe cooled, dark mixture is diluted with 75 ml
4. customof 10% ammonium hydroxide and a dark precipitate removed by filtration
5. extractionThe solid is extracted with methylene dichloride
6. customThe methylene dichloride is evaporated
7. customthe residue crystallized from ethyl acetate