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To a stirred, refluxing mixture of ethyl mercaptoacetate, and 4-chloro-1-(2-furyl)-1-butanol (Example 160), and sodium ethoxide in ethanol. The resulting mixture is stirred at reflux for 3 hours, cooled, and concentrated to remove most of the ethanol. The residue is partitioned with ether and water. The ether phase is washed with brine and dried over potassium carbonate. The solution is concentrated, diluted with xylene, and again conentrated to give an oil.

1. temperatureTo a stirred, refluxing
2. temperatureat reflux for 3 hours
3. temperaturecooled
4. concentrationconcentrated
5. customto remove most of the ethanol
6. customThe residue is partitioned with ether and water
7. washThe ether phase is washed with brine
8. dry with materialdried over potassium carbonate
9. concentrationThe solution is concentrated
10. additiondiluted with xylene
11. customto give an oil