反应详情

温度

45 °C

A solution of 2-(formylamino)-4-(1-naphthyloxy)butanol (7.1 g), prepared as described in Example 3, in dry THF (150 ml) is added dropwise to a suspension of LiAlH4 (5.0 g) in THF (150 ml). The mixture is heated at 45° C. for 3 hours and cooled. Excess LiAlH4 is destroyed by the careful addition of THF/water (9:1). The mixture is filtered through diatomaceous earth (Celite). The filtrate is dried and evaporated. The residue is crystallized from diethyl ether to give the title compound, γmaxCHCl3 3650, 3352, 1595 and 1580 cm-1.

1. temperaturecooled
2. customExcess LiAlH4 is destroyed by the careful addition of THF/water (9:1)
3. filtrationThe mixture is filtered through diatomaceous earth (Celite)
4. customThe filtrate is dried
5. customevaporated
6. customThe residue is crystallized from diethyl ether