Phosgene → 3-Chloro-4-fluorophenyl isocyanate
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[C:10](Cl)(Cl)=[O:11]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([N:5]=[C:10]=[O:11])[CH:6]=[CH:7][C:8]=1[F:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 110 °C
Procedure
At -10° to 0° C. and while stirring, a solution of 156 parts by weight of 3-chloro-4-fluoroaniline (J. Chem. Soc., 1928, 423) is metered into a solution of 250 parts by weight of phosgene in 1,000 parts by weight of toluene. The mixture is slowly heated to 110° C. (internal temperature), at which temperature it becomes clear.
Sources & evidence
- ORD record
- ord-73ed7aefaa43420fb8f997a205cc8c1d
- Source dataset
- uspto-grants-1978_12
- Patent number
- US04131751
Reaction notes
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