HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → 3-Chloro-4-fluorophenyl isocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Chloro-4-fluorophenyl isocyanate | HCID 2734632 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
At -10° to 0° C. and while stirring, a solution of 156 parts by weight of 3-chloro-4-fluoroaniline (J. Chem. Soc., 1928, 423) is metered into a solution of 250 parts by weight of phosgene in 1,000 parts by weight of toluene. The mixture is slowly heated to 110° C. (internal temperature), at which temperature it becomes clear.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04131751 |
| Source dataset | uspto-grants-1978_12 |
| ORD ID | ord-73ed7aefaa43420fb8f997a205cc8c1d |
| Source note | uspto-grants-1978_12 |