反应详情

In a 500 mL 3 necked rb flask equipped with a mechanical stirrer, condensor and addition funnel, a THF solution of 1-(3,4-dimethoxyphenyl)-2-nitro-7-(4-methylphenyl)-5-heptanone ethylene ketal (15.7 g; 0.037 mole) was added slowly to a suspension of LiAlH4 (14.2 g; 0.111 mole) in dry THF. The reaction was refluxed for 2 hours. Excess LiAlH4 was then decomposed with sat. Na2SO4, the salts filtered and the organic layer dried over MgSO4, filtered and concentrated to yield 14.2 g of a brown oil.

1. additioncondensor and addition funnel
2. temperatureThe reaction was refluxed for 2 hours
3. filtrationthe salts filtered
4. dry with materialthe organic layer dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated