Dichloromethane → 1-isopropyl-6-(2-piperazin-1-yl-ethoxy)-1H-indole-4-carboxylic acid (6-methyl-2-oxo-4-propyl-1,2-dihydro-pyridin-3-ylmethyl)-amide

HRID 664687Notes

Reaction equation

HRID 664687 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][O:16][c:17]2[cH:18][c:19]([C:29]([NH:30][CH2:31][c:32]3[c:33](=[O:42])[nH:34][c:35]([CH3:41])[cH:36][c:37]3[CH2:38][CH2:39][CH3:40])=[O:43])[c:20]3[cH:21][cH:22][n:23]([CH:26]([CH3:27])[CH3:28])[c:24]3[cH:25]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:51][CH2:52][Cl:53].[F:44][C:45]([F:46])([F:47])[C:48]([OH:49])=[O:50]>>[NH:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][O:16][c:17]2[cH:18][c:19]([C:29]([NH:30][CH2:31][c:32]3[c:33](=[O:42])[nH:34][c:35]([CH3:41])[cH:36][c:37]3[CH2:38][CH2:39][CH3:40])=[O:43])[c:20]3[cH:21][cH:22][n:23]([CH:26]([CH3:27])[CH3:28])[c:24]3[cH:25]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67465404HCID 67465404, compound

Product 1

HCID 674688131-isopropyl-6-(2-piperazin-1-yl-ethoxy)-1H-indole-4-carboxylic acid (6-methyl-2-oxo-4-propyl-1,2-dihydro-pyridin-3-ylmethyl)-amide

Sources & evidence

ORD record
ord-e0b668b956a0436ab4d284f3ff8cbe47
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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