Dichloromethane → 2-(4-Chloro-phenyl)-4-(2-hydroxy-ethyl)-thiazole-5-carboxylic acid [1-(2-pyrrolidin-1-yl-ethyl)-1H-indol-5-yl]-amide

HRID 664904Notes

Reaction equation

HRID 664904 reaction equation
[CH3:18][Al:19]([CH3:20])[CH3:21].[Cl:22][c:23]1[cH:24][cH:25][c:26](-[c:29]2[s:30][c:31]3[c:32]([n:33]2)[CH2:34][CH2:35][O:36][C:37]3=[O:38])[cH:27][cH:28]1.[Cl:39][CH2:40][Cl:41].[N:1]1([CH2:6][CH2:7][n:8]2[cH:9][cH:10][c:11]3[cH:12][c:13]([NH2:17])[cH:14][cH:15][c:16]23)[CH2:2][CH2:3][CH2:4][CH2:5]1>>[N:1]1([CH2:6][CH2:7][n:8]2[cH:9][cH:10][c:11]3[cH:12][c:13]([NH:17][C:37]([c:31]4[s:30][c:29](-[c:26]5[cH:25][cH:24][c:23]([Cl:22])[cH:28][cH:27]5)[n:33][c:32]4[CH2:34][CH2:35][OH:36])=[O:38])[cH:14][cH:15][c:16]23)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 113905745-Amino-1-(2-pyrrolidin-1-ylethyl)indoleHCID 16682925TrimethylaluminumHCID 574214852-(4-Chloro-phenyl)-6,7-dihydro-pyrano[4,3-d]thiazol-4-one

Product 1

HCID 578702492-(4-Chloro-phenyl)-4-(2-hydroxy-ethyl)-thiazole-5-carboxylic acid [1-(2-pyrrolidin-1-yl-ethyl)-1H-indol-5-yl]-amide

Sources & evidence

ORD record
ord-05dfee7295ce4fc9b61ebf5aa413eeb6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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