Acetone → tert-Butyl 3-hydroxy-4-oxopiperidine-1-carboxylate

HRID 665123Notes

Reaction equation

HRID 665123 reaction equation
[CH3:30][C:31](=[O:32])[CH3:33].[OH:1][CH:2]1[CH2:3][N:4]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:5][CH2:6][C:7]1([O:8][CH3:11])[O:9][CH3:10].[c:19]1([CH3:20])[cH:21][cH:22][c:23]([S:24]([OH:25])(=[O:26])=[O:27])[cH:28][cH:29]1>>[OH:1][CH:2]1[CH2:3][N:4]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:5][CH2:6][C:7]1=[O:8]

Participants

4

Reactant 3

HCID 180AcetoneHCID 6101p-Toluenesulfonic acidHCID 11425480Tert-butyl 3-hydroxy-4,4-dimethoxypiperidine-1-carboxylate

Product 1

HCID 58116959tert-Butyl 3-hydroxy-4-oxopiperidine-1-carboxylate

Sources & evidence

ORD record
ord-cbf2722ad36243f78624d63c4771523f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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