L-Proline → HCID 70542463, compound

HRID 66543Notes

Reaction equation

HRID 66543 reaction equation
[C:1]1([C:6]([CH2:8]/[CH:9]=[CH:10]/[C:11]([OH:13])=O)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.[NH:14]1[CH2:21][CH2:20][CH2:19][C@H:15]1[C:16]([OH:18])=[O:17]>O1CCCC1>[C:1]1([C:6]([CH2:8]/[CH:9]=[CH:10]/[C:11]([N:14]2[CH2:21][CH2:20][CH2:19][C@H:15]2[C:16]([OH:18])=[O:17])=[O:13])=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 145742L-ProlineHCID 20529989HCID 20529989, compound

Product 1

HCID 70542463HCID 70542463, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of 0.01 mole of 4-(2-thenoyl)crotonic acid in 50 ml. of tetrahydrofuran is added 0.011 mole of N,N'-carbonyldiimidazole. After stirring for 2 hours, L-proline (0.01 mole) is added and the mixture is stirred for 24 hours at room temperature and refluxed for one hour to give 1-[4-(2-thenoyl)crotonyl]-L-proline.

Workup

  1. stirringthe mixture is stirred for 24 hours at room temperature
  2. temperaturerefluxed for one hour

Sources & evidence

ORD record
ord-9f72375644df40cdbb69bb76e76f7c21
Source dataset
uspto-grants-1982_08
Patent number
US04342691

Reaction notes

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