Acetic Acid → [4-Amino-4-(2,3-difluorophenyl)-2-(trifluoromethyl)oxolan-3-yl]methanol

HRID 665489Notes

Reaction equation

HRID 665489 reaction equation
[CH3:21][C:22](=[O:23])[OH:24].[CH3:25][CH2:26][O:27][C:28]([CH3:29])=[O:30].[F:1][c:2]1[c:3]([C:9]23[NH:10][O:11][CH2:12][CH:13]2[CH:14]([C:17]([F:18])([F:19])[F:20])[O:15][CH2:16]3)[cH:4][cH:5][cH:6][c:7]1[F:8].[Zn:31]>>[F:1][c:2]1[c:3]([C:9]2([NH2:10])[CH:13]([CH2:12][OH:11])[CH:14]([C:17]([F:18])([F:19])[F:20])[O:15][CH2:16]2)[cH:4][cH:5][cH:6][c:7]1[F:8]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 8857Ethyl AcetateHCID 23994ZincHCID 774594066a-(2,3-difluorophenyl)-4-(trifluoromethyl)-3,3a,4,6-tetrahydro-1H-furo[3,4-c][1,2]oxazole

Product 1

HCID 77977375[4-Amino-4-(2,3-difluorophenyl)-2-(trifluoromethyl)oxolan-3-yl]methanol

Sources & evidence

ORD record
ord-361c968d52054bc6b279a0ced846d616
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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