反应详情

21-Chloro-21-(phenylsulfinyl)pregna-4,9(11),17(20),20-tetraen-3-one, (V, Example 2, 100 mg) and THF (1 ml) are slurried and cooled to 0°-5° under nitrogen. Sodium methoxide in methanol (25%, 0.05 ml) is added with stirring. The mixture is stirred 1 hr and then quenched with water (10 ml). The mixture is extracted with ethyl acetate (2×15 ml). The organic extracts are combined, backwashed with water (10 ml), dried over sodium sulfate and concentrated under reduced pressure to give the title compound.

1. temperaturecooled to 0°-5° under nitrogen
2. stirringThe mixture is stirred 1 hr
3. customquenched with water (10 ml)
4. extractionThe mixture is extracted with ethyl acetate (2×15 ml)
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure