Dichloromethane → 3-(Piperazin-1-yl)-3-oxopropionic acid [4-phenyl-1-(3-phenyl-propyl)-butyl]-amide

HRID 665535Notes

Reaction equation

HRID 665535 reaction equation
[CH2:46]([Cl:47])[Cl:48].[OH:39][C:40]([C:41]([F:42])([F:43])[F:44])=[O:45].[c:1]1([CH2:7][CH2:8][CH2:9][CH:10]([CH2:11][CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[NH:20][C:21]([CH2:22][C:23](=[O:24])[N:25]2[CH2:26][CH2:27][N:28]([C:31]([O:32][C:33]([CH3:34])([CH3:35])[CH3:36])=[O:37])[CH2:29][CH2:30]2)=[O:38])[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([CH2:7][CH2:8][CH2:9][CH:10]([CH2:11][CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[NH:20][C:21]([CH2:22][C:23](=[O:24])[N:25]2[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]2)=[O:38])[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 206224113-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-3-oxopropionic acid [4-phenyl-1-(3-phenyl-propyl)-butyl]-amide

Product 1

HCID 129924703-(Piperazin-1-yl)-3-oxopropionic acid [4-phenyl-1-(3-phenyl-propyl)-butyl]-amide

Sources & evidence

ORD record
ord-f091fa4dc55d4040b2f40cde60581747
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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