反应详情

Erythro, 1-(1,4-benzodioxan-2-yl)-2-bromoethanol (1.29 g, 0.005 m) and 2-(piperid-4-yl)-1H-isoindole-1,3-(2H)dione hydrochloride (1.33 g, 0.005 cm3) in ethanol (75 cm3) with triethylamine (3.03 g, 0.03 cm3) were refluxed for 18 hours. The solution was cooled and the solvent evaporated. the residue was dissolved in chloroform and then washed twice with water, dried (MgSO4) and evaporated. The residue was dissolved in isopropyl alcohol and acidified with ethanolic HCl. The crystallised material was filtered to give the title compound as the hydrochloride salt m.p. 235°-237° C.

1. temperatureThe solution was cooled
2. customthe solvent evaporated
3. dissolutionthe residue was dissolved in chloroform
4. washwashed twice with water
5. dry with materialdried (MgSO4)
6. customevaporated
7. dissolutionThe residue was dissolved in isopropyl alcohol
8. filtrationThe crystallised material was filtered