反应详情

To a solution of 2-(2-methylguanidino)-4-(3-aminocyclohexyl)thiazole (0.5 g.) in methanol (15 ml.) was added dimethyl(cyanoimido)dithiocarbonate (0.3 g.) and the resulting solution allowed to stand at room temperature overnight. Concentration of the reaction mixture gave 2-(2-methylguanidino)-4-[3-(3-cyano-2-methylisothioureido)cyclohexyl]thiazole, m.p. 200°-204° (decomp.).