2-(2-Methylguanidino)-4-(3-aminocyclohexyl)thiazole → HCID 178485102, compound

HRID 66575Notes

Reaction equation

HRID 66575 reaction equation
[CH3:1][N:2]=[C:3]([NH2:17])[NH:4][C:5]1[S:6][CH:7]=[C:8]([CH:10]2[CH2:15][CH2:14][CH2:13][CH:12]([NH2:16])[CH2:11]2)[N:9]=1>CO>[CH3:1][N:2]=[C:3]([NH2:17])[NH:4][C:5]1[S:6][CH:7]=[C:8]([CH:10]2[CH2:15][CH2:14][CH2:13][CH:12]([NH:16][C:5](=[N:4][C:3]#[N:2])[S:6][CH3:7])[CH2:11]2)[N:9]=1

Participants

3

Reactant 1

HCID 205303852-(2-Methylguanidino)-4-(3-aminocyclohexyl)thiazole

Product 1

HCID 178485102HCID 178485102, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-(2-methylguanidino)-4-(3-aminocyclohexyl)thiazole (0.5 g.) in methanol (15 ml.) was added dimethyl(cyanoimido)dithiocarbonate (0.3 g.) and the resulting solution allowed to stand at room temperature overnight. Concentration of the reaction mixture gave 2-(2-methylguanidino)-4-[3-(3-cyano-2-methylisothioureido)cyclohexyl]thiazole, m.p. 200°-204° (decomp.).

Sources & evidence

ORD record
ord-f7c602eb40e2463696c6ee4f002537ad
Source dataset
uspto-grants-1982_08
Patent number
US04342765

Reaction notes

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