反应详情

To a solution of 2-(2-methylguanidino)-4-(3-aminocyclohexyl)thiazole (0.3 g.) in ethanol (50 ml.) was added methylisothiocyanate (0.1 g.) and the solution heated under reflux for 2 hours. Evaporation of the reaction mixture and crystallisation of the residue from methanol/ethyl acetate gave 2-(2-methylguanidino)-4-[3-(3-methylthioureido)cyclohexyl]thiazole (0.35 g.), m.p. 214°-215° (decomp.).

1. temperaturethe solution heated
2. temperatureunder reflux for 2 hours
3. customEvaporation of the reaction mixture and crystallisation of the residue from methanol/ethyl acetate