HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → 2-(2-Methylguanidino)-4-[3-(3-methylthioureido)cyclohexyl]thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 2-(2-Methylguanidino)-4-(3-aminocyclohexyl)thiazole | HCID 20530385 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(2-Methylguanidino)-4-[3-(3-methylthioureido)cyclohexyl]thiazole | HCID 20530384 | 90.5% |
Reaction Steps
To a solution of 2-(2-methylguanidino)-4-(3-aminocyclohexyl)thiazole (0.3 g.) in ethanol (50 ml.) was added methylisothiocyanate (0.1 g.) and the solution heated under reflux for 2 hours. Evaporation of the reaction mixture and crystallisation of the residue from methanol/ethyl acetate gave 2-(2-methylguanidino)-4-[3-(3-methylthioureido)cyclohexyl]thiazole (0.35 g.), m.p. 214°-215° (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04342765 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-01cec03b83f148ffadff8b066265cf51 |
| Source note | uspto-grants-1982_08 |