反应详情

A solution of 1-[3-(2-guanidinothiazol-4-yl)cyclohexylamino]-2-methoxycyclobutene-3,4-dione (0.25 g.) in warm methanol/chloroform (50:50 v/v) (50 ml.) was treated with 14 ml. of a solution of methylamine in ethanol (33% w/v) and the resulting solution allowed to stand at room temperature for 2 hours. Concentration of the reaction mixture gave a crystalline solid (0.21 g.) which was collected and washed with a small volume of methanol to give 1-[3-(2-guanidinothiazol-4-yl)cyclohexylamino]-2-methylaminocyclobutene-3,4-dione, obtained as the hemihydrate, m.p. 263°-268° (decomp.).

1. customConcentration of the reaction mixture gave a crystalline solid (0.21 g.) which
2. customwas collected
3. washwashed with a small volume of methanol