反应详情

A solution of 2-guanidino-4-[3-(3-methylsulphonyl-2-methylisothioureido)cyclohexyl]thiazole (0.25 g.) in methanol/chloroform 50:50 v/v (15 ml.) was treated with 20 ml. of 33% w/v methylamine in ethanol and the mixture allowed to stand at room temperature overnight. Evaporation of the solvent gave a gum which was dissolved in methanol (1 ml.) and to this solution was added an excess of maleic acid in acetone. The resulting solution was diluted with ether until crystallisation occurred, giving 2-guanidino-4-[3-(2-methylsulphonyl-3-methylguanidino)cyclohexyl]-thiazole hydrogen maleate monohydrate, m.p. 184°-187° (decomp).

1. customEvaporation of the solvent
2. customgave a gum which