Dimethyl Sulfoxide → Tert-butyl 2-formyl-4-phenylmethoxypyrrolidine-1-carboxylate

HRID 666018Notes

Reaction equation

[C:18]([CH3:19])([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH:26]([CH2:38][OH:39])[CH2:27][CH:28]([O:30][CH2:31][c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[CH2:29]1.[CH2:44]([O:45][CH2:46][CH3:47])[CH3:48].[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[CH3:40][S:41](=[O:42])[CH3:43].[S:14](=[O:15])(=[O:16])=[O:17].[n:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>>[C:18]([CH3:19])([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH:26]([CH:38]=[O:39])[CH2:27][CH:28]([O:30][CH2:31][c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[CH2:29]1

Participants

Reactant 6

HCID 679Dimethyl Sulfoxide

HCID 1049Pyridine

HCID 3283Diethyl Ether

HCID 8471Triethylamine

HCID 24682Sulfur trioxide

HCID 14821718(2S,4R)-tert-butyl 4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Product 1

HCID 14863945Tert-butyl 2-formyl-4-phenylmethoxypyrrolidine-1-carboxylate

Sources & evidence

ORD record: ord-d07f90aa7bb24587bc982e5ca56c393d
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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