反应详情

A mixture of 1-fluoro-3-(4-methoxyphenyl)-2-propanone (4.1 g, 0.0225 mol), ammonium chloride (1.5 g) and 28% aqueous ammonia (27 ml) is treated with sodium cyanide (1.4 g), and the mixture is stirred at room temperature overnight under nitrogen. The oil which separates is removed and extracted with diethyl ether, and the ethereal extract is washed with ammonia, dried (MgSO4), and filtered. Evaporation of the ether leaves an oily residue which is washed with pentane by decantation. An NMR analysis of the oily residue (4 g) shows that it consists mainly of the required 2-amino-2-fluoromethyl-3-(4-methoxyphenyl)propionitrile.

1. customThe oil which separates is removed
2. extractionextracted with diethyl ether
3. extractionthe ethereal extract
4. washis washed with ammonia
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. customEvaporation of the ether
8. customleaves an oily residue which
9. washis washed with pentane by decantation