Bicarbonate Ion → 3-Amino-6-(2,3-difluorophenyl)-1-(1,3-thiazol-2-ylmethyl)azepan-2-one
Reaction equation
[C:48](=[O:49])([OH:50])[O-:51].[Cl:45][CH2:46][Cl:47].[F:1][c:2]1[c:3]([CH:9]2[CH2:10][CH2:11][CH:12]([N:23]([C:24]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:30])[C:31]([O:32][C:33]([CH3:34])([CH3:35])[CH3:36])=[O:37])[C:13](=[O:22])[N:14]([CH2:16][c:17]3[s:18][cH:19][cH:20][n:21]3)[CH2:15]2)[cH:4][cH:5][cH:6][c:7]1[F:8].[Na+:52].[OH:38][C:39]([C:40]([F:41])([F:42])[F:43])=[O:44]>>[F:1][c:2]1[c:3]([CH:9]2[CH2:10][CH2:11][CH:12]([NH2:23])[C:13](=[O:22])[N:14]([CH2:16][c:17]3[s:18][cH:19][cH:20][n:21]3)[CH2:15]2)[cH:4][cH:5][cH:6][c:7]1[F:8]Participants
6
Sources & evidence
- ORD record
- ord-1e9d1b236f984c6f9f04696fd30d8114
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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