Potassium Cation → tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(4-phenyl-butoxy)-phenyl]-piperidine-1-carboxylate

HRID 666634Notes

Reaction equation

HRID 666634 reaction equation
[C:38](=[O:39])([O-:40])[O-:41].[CH3:22][S:23]([OH:24])(=[O:25])=[O:26].[K+:42].[K+:43].[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([OH:14])[cH:12][cH:13]1.[c:27]1([CH2:33][CH2:34][CH2:35][CH2:36][OH:37])[cH:28][cH:29][cH:30][cH:31][cH:32]1>>[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([O:14][CH2:36][CH2:35][CH2:34][CH2:33][c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[cH:12][cH:13]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6395Methanesulfonic AcidHCID 19660Carbonate IonHCID 76889BenzenebutanolHCID 21713087(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate

Product 1

HCID 54504409tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(4-phenyl-butoxy)-phenyl]-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-294ba520f080421d91651002a4d6eeaa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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