反应详情

To a stirred mixture of 80 parts of sodium methoxide and 160 parts of methanol are added successively 50 parts of 2-thiopheneacetonitrile and then dropwise 66 parts of 1-(phenylmethyl)-4-piperidinone. Upon completion, the whole is heated to reflux and stirring at reflux temperature is continued for one hour. The reaction mixture is cooled and evaporated. The residue is distilled in a molecular distillation-apparatus, yielding about 70 parts of α-[1-(phenylmethyl)-4-piperidinylidene]-2-thiopheneacetonitrile as a residue.

1. temperatureUpon completion, the whole is heated
2. temperatureto reflux
3. temperatureat reflux temperature
4. temperatureThe reaction mixture is cooled
5. customevaporated
6. distillationThe residue is distilled in a molecular distillation-apparatus