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N-苄基哌啶酮 → alpha-[1-(Phenylmethyl)-4-piperidinylidene]-2-thiopheneacetonitrile
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | N-苄基哌啶酮 | HCID 19220 | — |
| 反应物 | 2-噻吩乙腈 | HCID 72880 | — |
| 反应物 | 甲醇钠 | HCID 10942334 | — |
| 溶剂 | (5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮 | HCID 887 | — |
| 产物 | alpha-[1-(Phenylmethyl)-4-piperidinylidene]-2-thiopheneacetonitrile | HCID 20278965 | — |
反应步骤
To a stirred mixture of 80 parts of sodium methoxide and 160 parts of methanol are added successively 50 parts of 2-thiopheneacetonitrile and then dropwise 66 parts of 1-(phenylmethyl)-4-piperidinone. Upon completion, the whole is heated to reflux and stirring at reflux temperature is continued for one hour. The reaction mixture is cooled and evaporated. The residue is distilled in a molecular distillation-apparatus, yielding about 70 parts of α-[1-(phenylmethyl)-4-piperidinylidene]-2-thiopheneacetonitrile as a residue.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US04342870 |
| 来源数据集 | uspto-grants-1982_08 |
| ORD ID | ord-bff8e7e8b5594c60a316a287b3fb0b1f |
| 来源说明 | uspto-grants-1982_08 |