反应详情

To a stirred mixture of 29.6 parts of 1-(phenylmethyl)-α-(2-thienyl)-4-piperidineacetonitrile in 100 parts of dimethyl sulfoxide are added portionwise 4 parts of a sodium hydride dispersion 60%. Upon completion, stirring is continued overnight. The reaction mixture is poured onto water. The precipitated product is filtered off and extracted with trichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from 2,2'-oxybispropane, yielding 10 parts (35%) of [1-(phenylmethyl)-4-piperidinyl](2-thienyl)methanone; mp. 100.5° C.

1. additionThe reaction mixture is poured onto water
2. filtrationThe precipitated product is filtered off
3. extractionextracted with trichloromethane
4. customThe extract is dried
5. filtrationfiltered
6. customevaporated
7. customThe residue is crystallized from 2,2'-oxybispropane