反应详情

A mixture of 12 parts of ethyl carbonochloridate, 31 parts of (2-methylphenyl)[1-(phenylmethyl)-4-piperidinyl]methanone and 270 parts of dimethylbenzene is stirred and refluxed for 4 hours. The reaction mixture is evaporated and the residue is dissolved in trichloromethane. The solution is washed with a dilute hydrochloric acid solution. The organic phase is separated, dried, filtered and evaporated, yielding 20 parts of ethyl 4-(2-methylbenzoyl)-1-piperidinecarboxylate as an oily residue.

1. temperaturerefluxed for 4 hours
2. customThe reaction mixture is evaporated
3. dissolutionthe residue is dissolved in trichloromethane
4. washThe solution is washed with a dilute hydrochloric acid solution
5. customThe organic phase is separated
6. customdried
7. filtrationfiltered
8. customevaporated