反应详情

A mixture of 103 parts of ethyl 4-(4-methylbenzoyl)-1-piperidinecarboxylate and 900 parts of a hydrobromic acid solution 48% in water is stirred and refluxed for 3 hours. The reaction mixture is stirred and allowed to cool in an ice-bath. The precipitated product is filtered off, washed with water and stirred in 2-propanone, yielding 91 parts (86%) of (4-methylphenyl)(4-piperidinyl)methanone hydrobromide; mp. +300° C.

1. temperaturerefluxed for 3 hours
2. stirringThe reaction mixture is stirred
3. temperatureto cool in an ice-bath
4. filtrationThe precipitated product is filtered off
5. washwashed with water
6. stirringstirred in 2-propanone