Hydrochloric Acid → (+/-)-8-(4-Chlorophenyl)-5-azaspiro[2.5]octan-8-ol

HRID 666804Notes

Reaction equation

HRID 666804 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([OH:23])[CH2:9][CH2:10][N:11]([C:16]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])[CH2:12][C:13]23[CH2:14][CH2:15]3)[cH:6][cH:7]1.[ClH:24].[O:25]1[CH2:26][CH2:27][O:28][CH2:29][CH2:30]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([OH:23])[CH2:9][CH2:10][NH:11][CH2:12][C:13]23[CH2:14][CH2:15]3)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 57889946Tert-butyl 8-(4-chlorophenyl)-8-hydroxy-5-azaspiro[2.5]octane-5-carboxylate

Product 1

HCID 57889353(+/-)-8-(4-Chlorophenyl)-5-azaspiro[2.5]octan-8-ol

Sources & evidence

ORD record
ord-42ba30676d9945e0b7d5dd25029153d8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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