反应详情

A mixture of 40 parts of 1-acetyl-4-(4-fluoro-2-hydroxybenzoyl)piperidine and 150 parts of a hydrochloric acid solution 6N is stirred and refluxed for 3 hours. The reaction mixture is cooled. The precipitated product is filtered off, washed with 2-propanone and dried, yielding 29 parts (87%) of (4-fluoro-2-hydroxyphenyl)(4-piperidinyl)methanone hydrochloride; mp. +300° C.

1. temperaturerefluxed for 3 hours
2. temperatureThe reaction mixture is cooled
3. filtrationThe precipitated product is filtered off
4. washwashed with 2-propanone
5. customdried