反应详情

To a stirred solution of 2 parts of 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one in 32 parts of 2-propanol is added a solution of 0.59 parts of (Z)-2-butenedioic acid in 16 parts of 2-propanol. The product is allowed to crystallize. It is filtered off and dried, yielding 2.1 parts (82%) of 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (Z)-2-butenedioate (1:1); mp. 180.2° C.

1. customto crystallize
2. filtrationIt is filtered off
3. customdried