Triphenylphosphine → 2-[[3-Fluoro-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-[(4-fluorophenyl)methyl]-6-methylmorpholin-3-one

HRID 666904Notes

Reaction equation

HRID 666904 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:15])[CH:9]([OH:14])[O:10][CH:11]([CH3:13])[CH2:12]2)[cH:16][cH:17]1.[F:41][c:42]1[cH:43][c:44]([CH:45]=[O:46])[cH:47][cH:48][c:49]1-[n:50]1[cH:51][n:52][c:53]([CH3:55])[cH:54]1.[S:18]([Cl:19])([Cl:20])=[O:21].[c:22]1([P:23]([c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[cH:36][cH:37][cH:38][cH:39][cH:40]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:15])[C:9](=[CH:45][c:44]3[cH:43][c:42]([F:41])[c:49](-[n:50]4[cH:51][n:52][c:53]([CH3:55])[cH:54]4)[cH:48][cH:47]3)[O:10][CH:11]([CH3:13])[CH2:12]2)[cH:16][cH:17]1

Participants

5

Reactant 4

HCID 11776TriphenylphosphineHCID 24386Thionyl ChlorideHCID 690059084-[(4-Fluorophenyl)methyl]-2-hydroxy-6-methylmorpholin-3-oneHCID 707008423-Fluoro-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

Product 1

HCID 690055082-[[3-Fluoro-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-[(4-fluorophenyl)methyl]-6-methylmorpholin-3-one

Sources & evidence

ORD record
ord-f6263de23dff4df3b9a917c9c3bc4fad
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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