Hydrochloric Acid → 5-Bromo-1-methyl-3-(5,6,7,8-tetrahydro-1,6-naphthyridin-2-ylamino)pyridin-2(1H)-one

HRID 667077Notes

Reaction equation

HRID 667077 reaction equation
[Br:1][c:2]1[cH:3][c:4]([NH:10][c:11]2[n:12][c:13]3[c:18]([cH:19][cH:20]2)[CH2:17][N:16]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:15][CH2:14]3)[c:5](=[O:9])[n:6]([CH3:8])[cH:7]1.[CH2:29]([Cl:30])[Cl:31].[ClH:28].[O:32]1[CH2:33][CH2:34][O:35][CH2:36][CH2:37]1>>[Br:1][c:2]1[cH:3][c:4]([NH:10][c:11]2[n:12][c:13]3[c:18]([cH:19][cH:20]2)[CH2:17][NH:16][CH2:15][CH2:14]3)[c:5](=[O:9])[n:6]([CH3:8])[cH:7]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 58044254tert-Butyl 2-(5-Bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Product 1

HCID 580440655-Bromo-1-methyl-3-(5,6,7,8-tetrahydro-1,6-naphthyridin-2-ylamino)pyridin-2(1H)-one

Sources & evidence

ORD record
ord-eb4fcd6d24cc4a58a730e8a7012cf4d3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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