反应详情

Sodium hydride (0.10 mole) is added to 0.10 mole of benzyl alcohol in 100 ml. dry benzene and the mixture is refluxed 1-2 hours. The cooled solution is treated with 0.10 mole of 2,3-dichloropyrazine in 100 ml. of benzene. The mixture is refluxed for 20-60 hours, cooled, washed with water, dried, and evaporated and the product distilled in vacuo to give 2-chloro-3-benzyloxypyrazine.

1. temperatureThe mixture is refluxed for 20-60 hours
2. temperaturecooled
3. washwashed with water
4. customdried
5. customevaporated
6. distillationthe product distilled in vacuo