反应详情

Hydrogen peroxide (1.5 ml. of 30%) is added to a solution of 10 mmole of 2-chloro-6-methoxypyrazine in 5 ml. acetic acid. The solution is heated at 60°-75° C. for 10-15 hours. The solution is concentrated to quarter volume, diluted with water and extracted with chloroform, washed, dried and evaporated to give 2-chloro-6-methoxypyrazine 4-oxide which may be crystallized from a suitable solvent such as ethanol.

1. temperatureThe solution is heated at 60°-75° C. for 10-15 hours
2. concentrationThe solution is concentrated to quarter volume
3. additiondiluted with water
4. extractionextracted with chloroform
5. washwashed
6. customdried
7. customevaporated