Ammonium Hydroxide → 2-Amino-6-methoxypyrazine 4-oxide

HRID 66742Notes

Reaction equation

HRID 66742 reaction equation
Cl[C:2]1[CH:7]=[N+:6]([O-:8])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1.[OH-].[NH4+:12]>>[NH2:12][C:2]1[CH:7]=[N+:6]([O-:8])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 205289402-Chloro-6-methoxypyrazine 4-oxide

Product 1

HCID 205289822-Amino-6-methoxypyrazine 4-oxide

Procedure

2-Chloro-6-methoxypyrazine 4-oxide is treated with an excess of ammonium hydroxide in an autoclave at 150° C. for 14 hours. The reaction mixture is cooled and evaporated to dryness to give the crude product which may be used in the next step as is.

Workup

  1. temperatureThe reaction mixture is cooled
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-75ecce3c4fbf44649962e18d43f73347
Source dataset
uspto-grants-1982_08
Patent number
US04343802

Reaction notes

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