Ammonium Hydroxide → HCID 178508040, compound

HRID 66756Notes

Reaction equation

[OH:1][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][C:5](Br)=[CH:4][N:3]=1.[OH-].[NH4+:16]>>[OH:1][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][C:5]([NH2:16])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 178517602HCID 178517602, compound

Product 1

HCID 178508040HCID 178508040, compound

Procedure

A mixture of 2-hydroxy-3-morpholino-5-bromopyrazine (1g.) in 100 ml. of concentrated ammonium hydroxide is heated overnight at 100°-140° C. in a sealed tube to give 2-hydroxy-3-morpholino-5-aminopyrazine.

Sources & evidence

ORD record: ord-a2fd200e81034f6f9431faa72c7d4baa
Source dataset: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04343802

Reaction notes

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