4-Methylbenzenethiol → 2-[(4-Methylphenyl)thio]acetonitrile

HRID 66767Notes

Reaction equation

HRID 66767 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.Cl[CH2:10][C:11]#[N:12].C([O-])([O-])=O.[K+].[K+]>CS(C)=O>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:10][C:11]#[N:12])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 78114-MethylbenzenethiolHCID 7856ChloroacetonitrileHCID 11430Potassium Carbonate

Product 1

HCID 27997712-[(4-Methylphenyl)thio]acetonitrile

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The compound 4-methylthiophenoxyacetonitrile was prepared by heating 4-methylthiophenol, chloroacetonitrile and anhydrous K2CO3 in DMSO, employing substantially the same procedure described in previous examples.

Sources & evidence

ORD record
ord-135cec88a4434915a548520ac93a9dd3
Source dataset
uspto-grants-1982_08
Patent number
US04343808

Reaction notes

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