Dichloromethane → N-(4-(4-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazine-1-carbonyl)phenyl)-3-(1-methylcyclopropyl)propanamide

HRID 668104Notes

Reaction equation

HRID 668104 reaction equation
[CH3:1][C:2]1([CH2:5][CH2:6][C:7](=[O:8])[Cl:9])[CH2:3][CH2:4]1.[CH3:42][CH2:43][N:44]([CH2:45][CH3:46])[CH2:47][CH3:48].[Cl:49][CH2:50][Cl:51].[NH2:10][c:11]1[cH:12][cH:13][c:14]([C:17](=[O:18])[N:19]2[CH2:20][CH2:21][N:22]([CH2:25][c:26]3[cH:27][cH:28][c:29]([C:32]([C:33]([F:34])([F:35])[F:36])([C:37]([F:38])([F:39])[F:40])[OH:41])[cH:30][cH:31]3)[CH2:23][CH2:24]2)[cH:15][cH:16]1>>[CH3:1][C:2]1([CH2:5][CH2:6][C:7](=[O:8])[NH:10][c:11]2[cH:12][cH:13][c:14]([C:17](=[O:18])[N:19]3[CH2:20][CH2:21][N:22]([CH2:25][c:26]4[cH:27][cH:28][c:29]([C:32]([C:33]([F:34])([F:35])[F:36])([C:37]([F:38])([F:39])[F:40])[OH:41])[cH:30][cH:31]4)[CH2:23][CH2:24]3)[cH:15][cH:16]2)[CH2:3][CH2:4]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 583536463-(1-Methylcyclopropyl)propanoyl chlorideHCID 86638547(4-Aminophenyl)(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazin-1-yl)methanone

Product 1

HCID 86638548N-(4-(4-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazine-1-carbonyl)phenyl)-3-(1-methylcyclopropyl)propanamide

Sources & evidence

ORD record
ord-3b8c32ecfcaf4f30b3e2b570fcc21bd5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…